The three-volume set constitutes revised selected papers of the 21st International Conference on Information Security and Cryptology, Inscrypt 2025, held in Xi'an, China, during October 19-22, 2025. The 79 full papers presented in these proceedings were carefully reviewed and selected from 315 submissions. The papers were organized in the following topical sections: Part I : Post-Quantum Cryptography; Functional Encryption; Cryptanalysis and Implementations I; Cryptanalysis and Implementations II. Part II : Secure Multi-party Computation; Anomaly Detection Methodologies & Models; Network Security & Traffic Analysis. Part III : Privacy Preserving/Enhancing Technologies; AI and Security I; AI and Security II.